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	Provedor de dados BABT (1) BJPS (1) Autor Araújo,Elaine Bortoleti de (2) Benedetto,Raquel (1) Boas,Cristian Antonio Wieczorek Villas (1) Colturato,Maria Tereza (1) Massicano,Adriana Vidal Fernandes (1) Mengatti,Jair (1) Muramoto,Emiko (1) Silva,Jefferson Jesus (1) Mais... Palavra-chave 111In (1) Adenocarcinomas (1) Cetuximab (1) Head and neck cancer/diagnosis (1) Protein radioiodination (1) Radioimmunoconjugate/development (1) Radiopharmaceuticals (1) SPECT (1) Tumors diagnosis (1) VIP (1) VIP10-28 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2017 (1) 2005 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Comparative biodistribution profile of [131I]VIP and [131I]VIP10-28 BABT Colturato,Maria Tereza; Muramoto,Emiko; Araújo,Elaine Bortoleti de. Various tumor cells express significantly higher amounts of VIP receptors (VIPR) that provided the basis for the clinical use of radiolabeled VIP for the in vivo localization of tumors. This work studied the labeling of VIP and VIP10-28 with iodine-131 to compare the biological distribution of the labeled compounds in Nuce mice and the affinity for tumor cells. Both VIP and VIP10-28 peptides contain two tyrosine residues, in positions 10 and 22, that are theoretically equally susceptible to radioiodination employing oxidative electrophilic substitution using oxidizing agents like Chloramine T. Radiochemical purity of the reaction mixture was determined by electrophoresis and HPLC. The VIP peptide and the fragment were labeled with radioiodine with good... Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiopharmaceuticals; Protein radioiodination; VIP; VIP10-28; Adenocarcinomas. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700012 Development of radioimmunoconjugate for diagnosis and management of head-and-neck subclinical cancer and colorectal carcinoma BJPS Benedetto,Raquel; Massicano,Adriana Vidal Fernandes; Silva,Jefferson Jesus; Boas,Cristian Antonio Wieczorek Villas; Mengatti,Jair; Araújo,Elaine Bortoleti de. ABSTRACT Scientific innovations in diagnostic methods are important drivers of cancer control and prevention. Noninvasive imaging of the epidermal growth factor receptor (EGFR) in head-and-neck squamous, cell carcinoma and colorectal cancer could be valuable to select patients for EGFR-targeted therapy, as well as to monitor the efficacy and occurrence of resistance to immunotherapy. In order to develop the first Brazilian radioimmunoconjugate for diagnosis, Cetuximab has been conjugated to p-SCN-Bn-DTPA chelator and radiolabeled with Indium-111. The conjugation methodology was optimized using different mAb:DTPA molar ratios, time was then reduced for immunoconjugate preparation, besides the protein recovery’ percentage increased after purification (m =... Tipo: Info:eu-repo/semantics/article Palavras-chave: Radioimmunoconjugate/development; Head and neck cancer/diagnosis; Tumors diagnosis; Cetuximab; SPECT; 111In. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400624 Registros recuperados: 2 Primeira ... 1 ... Última

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