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	Provedor de dados 74 (2) Autor Araújo,Maria Cristina P. (2) Dias,Francisca da Luz (2) Takahashi,Catarina S. (2) Antunes,Lusânia M.G. (1) Cecchi,Andréa O. (1) Kronka,Sergio N. (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 1999 (1) 1998 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Chromosome damage induced by DNA topoisomerase II inhibitors combined with g-radiation in vitro 74 Araújo,Maria Cristina P.; Dias,Francisca da Luz; Cecchi,Andréa O.; Antunes,Lusânia M.G.; Takahashi,Catarina S.. Combined radiation and antineoplastic drug treatment have important applications in cancer therapy. In the present work, an evaluation was made of two known topoisomerase II inhibitors, doxorubicin (DXR) and mitoxantrone (MXN), with g-radiation. The effects of DXR or MXN on g-radiation-induced chromosome aberrations in Chinese hamster ovary (CHO) cells were analyzed. Two concentrations of each drug, 0.5 and 1.0 µg/ml DXR, and 0.02 and 0.04 µg/ml MXN, were applied in combination with two doses of g-radiation (20 and 40 cGy). A significant potentiating effect on chromosomal aberrations was observed in CHO cells exposed to 1.0 µg/ml DXR plus 40 cGy. In the other tests, the combination of g-radiation with DXR or MXN gave approximately additive effects. Reduced... Tipo: Info:eu-repo/semantics/article Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571998000300021 Effects of turmeric and its active principle, curcumin, on bleomycin-induced chromosome aberrations in Chinese hamster ovary cells 74 Araújo,Maria Cristina P.; Dias,Francisca da Luz; Kronka,Sergio N.; Takahashi,Catarina S.. Naturally occurring antioxidants have been extensively studied for their capacity to protect organisms and cells from oxidative damage. Many plant constituents including turmeric and curcumin appear to be potent antimutagens and antioxidants. The effects of turmeric and curcumin on chromosomal aberration frequencies induced by the radiomimetic agent bleomycin (BLM) were investigated in Chinese hamster ovary (CHO) cells. Three concentrations of each drug, turmeric (100, 250 and 500 <FONT FACE="Symbol">m</FONT>g/ml) and curcumin (2.5, 5 and 10 <FONT FACE="Symbol">m</FONT>g/ml), were combined with BLM (10 <FONT FACE="Symbol">m</FONT>g/ml) in CHO cells treated during the G1/S, S or G2/S phases of the cell cycle. Neither... Tipo: Info:eu-repo/semantics/article Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000300021 Registros recuperados: 2 Primeira ... 1 ... Última

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