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| Melo,Elayne Karine Souto de; Araujo,Thalita Pedon de; Silva,José Wellithom Viturino da; Chagas,Stephanye Carolyne Christino; Bedor,Danilo César Galindo; Santana,Davi Pereira de; Leal,Leila Bastos. |
| ABSTRACT Metronidazole (MTZ) is widely used as the standard antibiotic for the treatment of rosacea and, more recently, is being used off label in Brazilian hospitals for the treatment of wounds. Following oral administration, minimal amounts of active agent reaches the skin and side effects are strongly induced. Consequently, MTZ is currently being applied topically in order to improve the therapeutic efficacy with reduced side effects, with Rozex(r) (RZ) (an MTZ gelled formulation) being the only marketed product. This study examined whether the use of MTZ 0.75% from thermogel formulations could improve drug retention and reduce dermal exposure compared to that by Rozex(r). Following a 21 h permeation study, the highest total amount of MTZ permeated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Metronidazole/evaluation; Metronidazole/drug retention; Poloxamer 407; Rosacea/treatment; Dermatopharmacokinetic.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200626 |
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