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Risk factors for KPC-producing Klebsiella pneumoniae bacteremia BJID
Tuon,Felipe F.; Rocha,Jaime L.; Toledo,Paula; Arend,Lavinia N.; Dias,Camila H.; Leite,Talita M.; Penteado-Filho,Sergio R.; Pilonetto,Marcelo; Zavascki,Alexandre P..
The molecular epidemiology of carbapenemase-producing Klebsiella pneumoniae (KPC) has been largely investigated, but limited clinical information is available. A case-control study was performed to evaluate the risk factors for KPC bacteremia in hospitalized patients. Cases were patients with KPC bacteremia and controls were patients with non-KPC bacteremia. A total of 85 patients were included, 18 (21.2%) were KPC, and 67 (78.8%) were non-KPC (40 [59.7%] of them were extended-spectrum beta-lactamase producers). All KPC isolates were type 2 producers. These isolates belong to five distinct clones. Multivariate analysis showed that age (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.02 - 1.11; p = 0.004), presence of mechanical ventilation (OR,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Klebsiella pneumoniae; Bacteremia risk factors; Klebsiella pneumoniae; Carbapenemases; Carbapenems.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500002
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KPC-producing Enterobacter aerogenes infection BJID
Tuon,Felipe F.; Scharf,Camila; Rocha,Jaime L.; Cieslinsk,Juliette; Becker,Guilherme Nardi; Arend,Lavinia N..
Background: Enterobacteris a common nosocomial microorganism and its carbapenem's resistance has increased. The management of these cases is unclear.Objective: We evaluated 16 patients with KPC-producing Enterobacter aerogenesinfections, detailing the site of infection, therapy, clinical and epidemiological data.Methods: A retrospective and descriptive study. Clinical data were revised and KPC-2 detection was by molecular methods. Risk factors associated with mortality were compared using appropriate tests according to variable type with a significance level of 0.05.Results: The 30-day mortality rate was 37.5% with no association with inadequate treatment. Age (p= 0.004) and Charlson score of comorbidities (p= 0.048) were independent risk factors...
Tipo: Info:eu-repo/semantics/other Palavras-chave: KPC Enterobacter; Carbapenemase; Infection control.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300324
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Risk factors for mortality in patients with ventilator-associated pneumonia caused by carbapenem-resistant Enterobacteriaceae BJID
Tuon,Felipe F.; Graf,Maria Esther; Merlini,Alexandre; Rocha,Jaime L.; Stallbaum,Suellen; Arend,Lavinia N.; Pecoit-Filho,Roberto.
Abstract Background: The ideal therapeutic option for ventilator associated pneumonia caused by carbapenem-resistant Enterobacteriaceae is not defined. The aim of this study was to assess mortality-associated risk factors in patients with VAP by CRE and determine the outcome of several treatment options. Methods: This was a retrospective study performed in two tertiary hospitals involving patients with VAP caused by CRE between January 2010 and August 2014. The outcomes were mortality within 30 days of VAP diagnosis and overall mortality during hospital admission. Risk factors for mortality were assessed by comparing variables of survivors and non-survivors. Results: One hundred and twelve patients with CRE-VAP were included, 73 (65%) male, median age...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Carbapenemase-producing Klebsiella pneumoniae; Ventilator-associated pneumonia; Risk factors; Mortality; Treatment.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100001
Registros recuperados: 3
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