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| Saleem,Bushra; Islam,Muhammad; Saeed,Hamid; Imtiaz,Fariha; Asghar,Maryam; Saleem,Zikria; Mehmood,Azra; Naheed,Surriya. |
| ABSTRACT The leaves of Acacia modesta Wall. have been shown to possess diverse pharmacological properties. Therefore, we aimed at evaluating anti-diabetic, cytotoxic and proliferative effects of extracts of Acacia modesta Wall. leaves. After evaluating the primary and secondary metabolites, anti-diabetic activity of various extracts was assessed by α-amylase inhibition, glucose uptake by yeast cells and non-enzymatic glycosylation of hemoglobin assay. Cytotoxicity and proliferative potential was assessed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and short term proliferation assays, respectively, using human liver carcinoma cell line, HepG2. Among other extracts, chloroform extract exhibited 34.16% inhibition of α-amylase, 90.65%... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acacia modesta Wall; /anti-diabetic effects/cytotoxic/in vitro; MTT; Phytochemical. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200609 |
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