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Characteristic profile of antibody responses to PPD, ESAT-6, and CFP-10 of Mycobacterium tuberculosis in pulmonary tuberculosis suspected cases in Surabaya, Indonesia BJID
Dewi,Desak Nyoman Surya Suameitria; Mertaniasih,Ni Made; Soedarsono,; Ozeki,Yuriko; Artama,Wayan Tunas; Fihiruddin,; Niki,Mamiko; Tateishi,Yoshitaka; Ato,Manabu; Matsumoto,Sohkichi.
Abstract Accurate and rapid diagnostic tools are important aspects of managing tuberculosis (TB) cases appropriately. However, the sensitivity and specificity of diagnostic kits based on immune response such as the tuberculin skin test (TST) and interferon gamma release assay (IGRA) are still debated. Thus, the exploration and assessment of specific biomarker-targeted antibodies are needed for the development of an accurate and rapid diagnostic tool. The present study was conducted in patients with a respiratory problem suspected to be TB at Dr. Soetomo Hospital, Surabaya, Indonesia. Among 102 patients tested by GeneXpert and AFB, 59 serum samples were from cases retrospectively determined to have active TB. A total of 102 serum of healthy controls (HC)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antibody response' profile; PPD; Pulmonary tuberculosis; NTM.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400246
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