|
|
|
|
|
| Andrade,Luis Jesuino de Oliveira; Atta,Ajax Mercês; Atta,Maria Luiza Brito de Sousa; Mangabeira,Célia Neder Kalil; Paraná,Raymundo. |
| OBJECTIVE: To investigate the frequency of thyroid disorders (TD) in patients with chronic hepatitis C before and during interferon-alpha (IFN-α) and ribavirin (RIB) treatment. STUDY DESIGN: Prospective study. PATIENTS AND METHODS: We prospectively studied 65 anti-HCV and viral RNA positive patients. Free thyroxine, thyroid-stimulating hormone, and thyroid peroxidase antibodies (TPO-Ab) were systematically tested at entry (m0), week 12 (m3) and week 24 (m6) of treatment. RESULTS: Mean age of the 65 patients (38 females and 27 males) was 49.61 ± 11.83 years. Seven (10.76%) patients presented baseline thyroid disorders (m0), three had thyroid dysfunction, and four were TPO-Ab positive. Thyroid disorders occurred in the first 12 weeks of treatment in 11... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Hepatitis C; Interferon-alpha; Ribavirin; Thyroid diseases; Autoimmunity. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400013 |
| |
|
|
| Andrade,Luis Jesuino de Oliveira; Melo,Paulo Roberto Santana de; Atta,Ajax Mercês; Atta,Maria Luiza Brito de Sousa; Jesus,Larissa Santana de; Sousa,Gabriel Menezes de; Silva,Carolina Alves Costa; Paraná,Raymundo. |
| Cryoglobulinemia and non-organ-specific-autoantibody are biomarkers of autoimmunity of the chronic infection caused by hepatitis C virus (HCV). In this work, we report the association between the presence of smooth muscle antibodies (SMA) and cryoglobulinemia and chronic liver disease in HCV carriers. Sixty-five untreated HCV patients, 38 women and 27 men were included in this study. Cryoglobulinemia was tested by cryoprecipitation, SMA by indirect fluorescent antibody test, and liver fibrosis and hepatocellular inflammation activity was investigated by histology of liver biopsy using the METAVIR score. The prevalence of SMA in the patients was 33.8% and cryoglobulinemia was demonstrated in 36.9% patients. Cryoglobulinemia and SMA seropositivity was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C; Muscle; Smooth; Antibody specificity; Cryoglobulins; Liver diseases. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100012 |
| |
|
| |
|
|
|
