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Emerging Trends of Nanotechnology towards Picotechnology: Energy and Biomolecules Nature Precedings
Rakesh Sharma; Avdhesh Sharma; Ching J. Chen.
In nature, metal oxide particles display their existence at the level of picomolecules in solution state and bioactive states in the body. We present evidence of picomolar behavior of molecules different than nanomolar behavior of particles. These particles can be encapsulated in polymers and can be functionalized with protein, nucleotides, and drugs to develop as smart intracellular targeting pico-devices. The preparation technique and physiological conditions decide the size and functionality of these pico-carrier devices. Their usable success rate, feasibility and potentials are yet to be proven or we do not know. The major difference between nanodevices and pico-devices is their intermolecular and intramolecular thermodynamics in medium and their...
Tipo: Presentation Palavras-chave: Biotechnology; Chemistry.
Ano: 2010 URL: http://precedings.nature.com/documents/4525/version/1
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Nanotoxicity Assessment toward the Applications of Carbon Nanotubes as a Small Biomolecule Carrier in Drug Delivery Systems Nature Precedings
Rakesh Sharma; Soonjo Kwon; R Baktur; Avdhesh Sharma.
Carbon Nanotube (CNT) materials have superior properties in electric current carrying capacity, thermal conductivity, and thermal stability. Due to their structure with high aspect ratio, they have structural unusual toxicity and complicate safety issue in a target tissue. In optimized quantities with limited functionality, special type of CNT assembly such as “buckyball” can be used as a potential drug carrier of bioactive molecules and display with increased circulating time and acceptable functionality. We analyzed cytoxicity and inflammatory response following exposure of different size, mass, shape, and functionality of CNTs. We monitored the transport across skin, physiological perturbation of transepithelial electrical...
Tipo: Presentation Palavras-chave: Biotechnology.
Ano: 2009 URL: http://precedings.nature.com/documents/3948/version/1
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