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Implications of infectious diseases and the adrenal hypothesis for the etiology of childhood acute lymphoblastic leukemia BJMBR
Azevedo-Silva,F.; Camargo,B.de; Pombo-de-Oliveira,M.S..
Acute leukemia is the most frequent cancer in children. Recently, a new hypothesis was proposed for the pathogenesis of childhood acute lymphoblastic leukemia (ALL). The so-called "adrenal hypothesis" emphasized the role of endogenous cortisol in the etiology of B-cell precursor ALL. The incidence peak of ALL in children between 3 to 5 years of age has been well documented and is consistent with this view. The adrenal hypothesis proposes that the risk of childhood B-cell precursor ALL is reduced when early childhood infections induce qualitative and quantitative changes in the hypothalamus-pituitary-adrenal axis. It suggests that the increased plasma cortisol levels would be sufficient to eliminate all clonal leukemic cells originating during fetal life....
Tipo: Info:eu-repo/semantics/other Palavras-chave: Lymphoblastic leukemia; Childhood infections; Epidemiology; Kala-azar; Adrenal hypothesis.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000300001
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