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| NAEEM,MUHAMMAD; RAHMAN,NISAR UR; TAVARES,GUILHERME. D.; BARBOSA,SÁVIO F.; CHACRA,NÁDIA B.; LÖBENBERG,RAIMAR; SARFRAZ,MUHAMMAD K.. |
| ABSTRACTFlurbiprofen, a potent nonsteroidal anti-inflammatory drug, is widely used for relief of pain in patients suffering from rheumatic diseases, migraine, sore throat and primary dysmenorrheal. However, this drug has many gastrointestinal side effects produced by its oral administration, such as gastric bleeding and peptic ulcer. These effects were responsible for non-compliance among patients, which ultimately results in treatment failure. The physicochemical properties of flurbiprofen, make it a suitable candidate for transdermal drug delivery, which can overcome the drawbacks of oral administration. In this sense, microemulsions have been proved to increase the cutaneous absorption of lipophilic drugs when compared to conventional drug delivery... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Anti-inflammatory study; Flurbiprofen; Gels; In vitro permeation; Microemulsion. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000401823 |
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