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| LAHNECHE,AMINA M.; BOUCHEHAM,RATIBA; OZEN,TEVFIK; ALTUN,MUHAMMED; BOUBEKRI,NASSIMA; DEMIRTAS,IBRAHIM; BICHA,SABRINA; BENTAMENE,ALI; BENAYACHE,FADILA; BENAYACHE,SAMIR; ZAMA,DJAMILA. |
| Abstract: This study aimed to evaluate the in vitro antiproliferative and inhibition of oxidative DNA-damage activities of n-butanol (n-BuOH) extract of Centaurea sphaerocephala. The in vitro antioxidant activity of the ethyl acetate (EtOAc) and the n-BuOH extracts of this plant were also assayed. To investigate the antioxidant potential, extracts were tested for their capacity to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH·) and to inhibit lipid peroxidation using the TBARs method. The contents of total phenolics and flavonoids were measured. Additionally, antiproliferative activity and DNA-damage inhibition of the n-BuOH extract was determined using XCELLigence RTCA instrument and photolyzing 46966 plasmid, respectively. The results exhibited that the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Centaurea sphaerocephala; Phenolics; Antioxidant; Lipid peroxidation; Antiproliferative; DNA-damaged inhibition. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500619 |
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