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Interleukin-6 contributes to myocardial damage in pregnant rats with reduced uterine perfusion pressure BJMBR
Ding,Lan; Bai,Chuanming; Liu,Ying.
Preeclampsia is one of the most frequent and difficult illnesses in pregnancy, which jeopardizes both mother and fetus. There are several diagnostic criteria for preeclampsia. However, the preeclampsia-associated myocardial damage has not been described. In this study, we employed reduced uterine perfusion pressure (RUPP) to generate a rat model of preeclampsia for the evaluation of myocardial damage in late-gestation rats. The expressions of cardiac injury markers were analyzed by immunohistochemistry and ELISA. The arterial pressure and myocardial tissue velocities were also measured. The role of interleukin (IL)-6 in RUPP-associated myocardial damage was further explored. The results showed that RUPP rats had significant myocardial damage, as...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Preeclampsia; Myocardial damage; Reduced uterine perfusion pressure; Interleukin-6.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000800608
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