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| Baldoni,André Oliveira; Freitas-Lima,Priscila; Alexandre,Veriano; Ferreira,Flávia Isaura de Santi; Martinez,Edson Zangiacomi; Queiroz,Regina Helena Costa; Sakamoto,Americo Ceiki; Pereira,Leonardo Regis Leira. |
| ABSTRACT The purpose of this work was to evaluate the influence of the clinical profile on lamotrigine (LTG) plasma concentrations from patients with refractory epileptic seizures. In this cross-sectional study, therapeutic monitoring of LTG, and questionnaires with 75 patients with refractory epileptic seizures of a Hospital in Ribeirão Preto-SP-Brazil were performed. The multiple linear regression model was used to verify association between the LTG plasma concentrations and the independent variables. Covariance analysis was used to compare the mean LTG plasma concentration among the co-medication groups. The LTG plasma concentration was associated both with the LTG dosage (mg/kg/day) (p=0.0096) and with the use of first generation antiepileptic drugs... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lamotrigine; Refractory Epilepsy; Drug interaction; Therapeutic drug monitoring.. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200624 |
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| Reis,Tiago Marques dos; Guidoni,Camilo Molino; Baldoni,André Oliveira; Giroto,Edmarlon; Obreli Neto,Paulo Roque; Ayres,Lorena Rocha; Pereira,Leonardo Régis Leira. |
| ABSTRACT Dispensing drug is a moment in which the pharmacist is able to analyze pharmacotherapy and contribute to its rational use. However, research has shown that some pharmacists lack adequate knowledge to perform this service. This study aims to describe a research protocol for a clinical trial to test the effectiveness of a distance learning program to train pharmacists in dispensing drugs. This is a protocol for an open diagnostic, non-randomized, single group clinical trial. A 12-week duration distance learning course was structured on the Moodle platform for training community pharmacists who are registered in the Regional Board of Pharmacy and work as employees or owners in Brazilian community pharmacies. The course curricula involves concepts and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pharmacists/distant education; Pharmacists/dispensing of drugs; Pharmacists/continuing-education. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100605 |
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