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	Provedor de dados BJMBR (2) Autor Barbosa,A.L.R. (2) Souza,M.H.L.P. (2) Aragão,K.S. (1) Carvalho,N.S. (1) Costa,N.R.D. (1) Damasceno,S.R.B. (1) Medeiros,J.V.R. (1) Moraes,M.O. (1) Nicolau,L.A.D. (1) Oliveira,G.J. (1) Pinheiro,C.A. (1) Ribeiro,R.A. (1) Silva,R.O. (1) Soares,P.M.G. (1) Torres,J.N.L. (1) Vale,M.L. (1) Mais... Palavra-chave Alendronate (1) Carrageenan (1) Gastric damage (1) H2S donors (1) Hypernociception (1) Lawesson's reagent (1) Nitric oxide (1) Walker 246 tumor-bearing rats (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2013 (1) 2012 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última The hydrogen sulfide donor, Lawesson's reagent, prevents alendronate-induced gastric damage in rats BJMBR Nicolau,L.A.D.; Silva,R.O.; Damasceno,S.R.B.; Carvalho,N.S.; Costa,N.R.D.; Aragão,K.S.; Barbosa,A.L.R.; Soares,P.M.G.; Souza,M.H.L.P.; Medeiros,J.V.R.. Our objective was to investigate the protective effect of Lawesson's reagent, an H2S donor, against alendronate (ALD)-induced gastric damage in rats. Rats were pretreated with saline or Lawesson's reagent (3, 9, or 27 µmol/kg, po) once daily for 4 days. After 30 min, gastric damage was induced by ALD (30 mg/kg) administration by gavage. On the last day of treatment, the animals were killed 4 h after ALD administration. Gastric lesions were measured using a computer planimetry program, and gastric corpus pieces were assayed for malondialdehyde (MDA), glutathione (GSH), proinflammatory cytokines [tumor necrosis factor (TNF)-α and interleukin (IL)-1β], and myeloperoxidase (MPO). Other groups were pretreated with glibenclamide (5 mg/kg, ip) or with... Tipo: Info:eu-repo/semantics/article Palavras-chave: Alendronate; Lawesson's reagent; H2S donors; Gastric damage. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000800708 Participation of the NO/cGMP/K+ATP pathway in the antinociception induced by Walker tumor bearing in rats BJMBR Barbosa,A.L.R.; Pinheiro,C.A.; Oliveira,G.J.; Torres,J.N.L.; Moraes,M.O.; Ribeiro,R.A.; Vale,M.L.; Souza,M.H.L.P.. Implantation of Walker 256 tumor decreases acute systemic inflammation in rats. Inflammatory hyperalgesia is one of the most important events of acute inflammation. The L-arginine/NO/cGMP/K+ATP pathway has been proposed as the mechanism of peripheral antinociception mediated by several drugs and physical exercise. The objective of this study was to investigate a possible involvement of the NO/cGMP/K+ATP pathway in antinociception induced in Walker 256 tumor-bearing male Wistar rats (180-220 g). The groups consisted of 5-6 animals. Mechanical inflammatory hypernociception was evaluated using an electronic version of the von Frey test. Walker tumor (4th and 7th day post-implantation) reduced prostaglandin E2- (PGE2, 400 ng/paw; 50 µL; intraplantar injection)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Walker 246 tumor-bearing rats; Hypernociception; Nitric oxide; Carrageenan. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000600009 Registros recuperados: 2 Primeira ... 1 ... Última

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