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Development and evaluation of calcium alginate beads prepared by sequential and simultaneous methods BJPS
Mandal,Sanchita; Kumar,S. Senthil; Krishnamoorthy,Balakrishnam; Basu,Sanat Kumar.
The objective of this study was to develop a sustained release dosage form of Trimetazidine dihydrochloride (TMZ) using a natural polymeric carrier prepared in a completely aqueous environment. TMZ was entrapped in calcium alginate beads prepared with sodium alginate by the ionotropic gelation method using calcium chloride as a crosslinking agent. The drug was incorporated either into preformed calcium alginate gel beads (sequential method) or incorporated simultaneously during the gelation stage (simultaneous method). The beads were evaluated for particle size and surface morphology using optical microscopy and SEM, respectively. Beads produced by the sequential method had higher drug entrapment. Drug entrapment in the sequential method was higher with...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sodium alginate; Calcium alginate beads; Trimetazidine dihydrochloride; Ionotropic gelation.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400021
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