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The inhibitory role of sympathetic nervous system in the Ca2+-dependent proteolysis of skeletal muscle BJMBR
Navegantes,L.C.C.; Baviera,A.M.; Kettelhut,I.C..
Mammalian cells contain several proteolytic systems to carry out the degradative processes and complex regulatory mechanisms to prevent excessive protein breakdown. Among these systems, the Ca2+-activated proteolytic system involves the cysteine proteases denoted calpains, and their inhibitor, calpastatin. Despite the rapid progress in molecular research on calpains and calpastatin, the physiological role and regulatory mechanisms of these proteins remain obscure. Interest in the adrenergic effect on Ca2+-dependent proteolysis has been stimulated by the finding that the administration of β2-agonists induces muscle hypertrophy and prevents the loss of muscle mass in a variety of pathologic conditions in which calpains are activated. This review summarizes...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Epinephrine; Norepinephrine; Calpastatin; Calpain; Skeletal muscle.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100005
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