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	Provedor de dados BJID (1) BJPS (1) Autor Beck,Ruy Carlos Ruver (2) Araujo,Bibiana Verlindo de (1) Athayde,Margareth Linde (1) Cardoso,Simone Gonçalves (1) Chaves,Paula dos Santos (1) Fontana,Márcia Camponogara (1) Forgearini,Betielli (1) Laureano,João Víctor (1) Mais... Palavra-chave Antiretroviral therapy (1) Bioavailability. (1) Lamivudine (1) Liquid chromatography. (1) Plasma. (1) Public health (1) Quality control (1) Raloxifene/pharmacokinetic (1) Tablets (1) Zidovudine (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última HIV/AIDS treatment and physicochemical quality control of medicines: evaluation of non-generic lamivudine + zidovudine tablets manufactured in Brazil BJID Beck,Ruy Carlos Ruver; Athayde,Margareth Linde; Cardoso,Simone Gonçalves. In this work it was evaluated the physicochemical quality of lamivudine + zidovudine tablets, whose association belongs to the list of drugs distributed by the Brazil's National Program on Sexually Transmitted Diseases and AIDS. Four non-generic products (lamivudine + zidovudine tablets) were analyzed. They were obtained from different Brazilian manufacturers, besides a reference product. The quality was evaluated by physicochemical tests described in the official codes. A validated reversed-phase high performance liquid chromatography (HPLC) method was used for the assay of the active substances. All samples were in accordance to the requisites in relation to their physicochemical characteristics. Dissolution studies showed similar drug percentual... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antiretroviral therapy; Quality control; Lamivudine; Public health; Tablets; Zidovudine. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600003 LC-UV method to assay raloxifene hydrochloride in rat plasma and its application to a pharmacokinetic study BJPS Fontana,Márcia Camponogara; Laureano,João Víctor; Forgearini,Betielli; Chaves,Paula dos Santos; Araujo,Bibiana Verlindo de; Beck,Ruy Carlos Ruver. A specific, precise, and accurate LC-UV method was developed and validated to assay raloxifene hydrochloride in rat plasma. Raloxifene was analyzed after liquid-liquid extraction and quantified by reversed phase liquid chromatography (C18 column) using acetonitrile and ammonium acetate buffer 0.05 M (pH 4.0) as mobile phase at a flow rate of 1 mL.min-1 and UV detection at 287 nm. Retention times of raloxifene and internal standard (dexamethasone) were approximately 11 min and 14 min, respectively. Linearity was checked for a concentration range between 25 ng.mL-1 and 1000 ng.mL-1. Intra- and inter-day precision had relative standard deviation lower than 10% and 15%, respectively. Recovery from plasma was higher than 90%. Accuracy values were 98.21%,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Raloxifene/pharmacokinetic; Liquid chromatography.; Plasma.; Bioavailability.. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100538 Registros recuperados: 2 Primeira ... 1 ... Última

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