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Amphotericin B-related nephrotoxicity in low-risk patients BJID
Berdichevski,Roberto Herz; Luis,Luciano Billodre; Crestana,Letícia; Manfro,Roberto Ceratti.
INTRODUCTION: Amphotericin B (AmphoB) is the drug of choice for treatment of severe fungal illnesses; however, it is very nephrotoxic. Modified (less toxic) amphotericins are very expensive. In low-risk patients, saline loading would be enough to prevent significant loss of renal function. MATERIAL AND METHODS: Patients with normal renal function and within the first 24 hours of treatment with AmphoB were prospectively enrolled in the study. Patients in intensive care units or who were using vasoactive drugs were excluded. Saline loads were infused before and after the AmphoB treatment. Blood and urine analyses were made at the beginning and at the end of the treatment. Serum creatinine was repeated 30 days after the end of the AmphoB treatment. RESULTS:...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amphotericin B; Acute renal failure; Nephrotoxicity; Sodium chloride.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200005
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