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| Actis,Andrea; Croci,Máximo; Bergoc,Rosa. |
| La búsqueda de alternativas terapéuticas para el tratamiento del cáncer de mama se ha extendido a distintas combinaciones de drogas, entre ellas, análogos de adenosina-3',5'-monofosfato cíclico (AMPc). De la amplia variedad existente, el 8-cloro-adenosina-3',5'-monofosfato cíclico (8-Cl-AMPc) es el más empleado, hallándose en fase de estudios clínicos. En este trabajo se analiza a nivel experimental, el efecto del compuesto, solo o combinado con otros agentes, sobre útero de ratón. Para ello, se administró a ratones Balb/c: 8-Cl-AMPc, tamoxifeno (Tam), y acetato de medroxiprogesterona (MPA), solos o combinados. Se halló que el peso del útero disminuyó por efecto del tratamiento con el 8-Cl-AMPc, sin modificación histológica importante de la mucosa uterina... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 8-cloro-adenosina-3'; 5'-monofosfato cíclico ratón útero tamoxifeno acetato de medroxiprogesterona histopatología. |
| Ano: 2005 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572005000200007 |
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| Mohamad,Nora; Gutiérrez,Alicia; Núñez,Mariel; Cocca,Claudia; Martín,Gabriela; Cricco,Graciela; Medina,Vanina; Rivera,Elena; Bergoc,Rosa. |
| Apoptosis or programmed cell death (PCD) is a physiological process characteristic of pluricellular organisms leading to self-destruction of the cell. It is therefore involved in development, homeostasis and host defense. However, a significant difference has been shown between mammalian cell apoptosis and non-mammalian cell apoptosis: mitochondria are implicated only in the former. Execution of PCD includes the release of several proapoptotic proteins from the intermembrane space of mitochondria. They could exert their actions through a caspase dependent as well as a caspase independent way. On the other hand, regulation of PCD is mainly given by the Bcl-2 family members, which are in turn essentially regulated by activation of death receptors and/or DNA... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Apoptosis; Mitochondria; Bcl-2 family; Cytochrome-c. |
| Ano: 2005 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452005000200001 |
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