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Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents Ciênc. Tecnol. Aliment.
Düsman,Elisângela; Berti,Alessandra Paim; Soares,Lilian Capelari; Vicentini,Veronica Elisa Pimenta.
Due to the large consumption of soft drinks in Brazil and worldwide in recent years and considering that some of the components present in their composition pose potential risks to human health, the aim of this study was to evaluate the cytotoxic and mutagenic potential of specific cola and grape-flavored soft drink brands. Bone marrow cells of Wistar rats were initially treated by gavage with one single dose of Cola or Grape soft drink, which was next offered ad libitum (instead of water) for 24 hours. A negative control treatment was performed by administering one single dose of water and a positive control administering cyclophosphamide intraperitoneally. Statistical analysis showed that the Cola and Grape soft drinks studied were not cytotoxic....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chromosomal aberration; Soft drinks; Wistar rats.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612013000100018
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Investigation of cytotoxic and mutagenic effects of Malpighia glabra L. (barbados cherry) fruit pulp and vitamin C on plant and animal test systems Ciênc. Tecnol. Aliment.
Düsman,Elisângela; Ferreira,Márcia Flores da Silva; Berti,Alessandra Paim; Mariucci,Rosinete Gonçalves; Mantovani,Mário Sérgio; Vicentini,Veronica Elisa Pimenta.
Fruits are important sources of nutrients in human diet, and Barbados Cherry (Malpighia glabra L.) is of particular interest due to its high content of antioxidants. Diets rich in fruits and vegetables protect individuals against diseases and cancer, but excessive intake of vitamins may act as pro-oxidant and generate changes in DNA. To evaluate the effect of different in natura (BAN) and frozen (BAF) Barbados Cherry pulp concentrations and synthetic vitamin C in liquid form (VC) on the chromosome level and the cell cycle division, root meristeme cells of Allium cepa L. and bone marrow cells of Wistar rats Rattus norvegicus, were used as test system. In Allium cepa L., BAN, at the highest concentration (0.4 mg.mL-1) and BAF, at the lowest concentration...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antioxidants; Cytotoxicity; Mutagenesis.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612012000200030
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