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	Provedor de dados J. Venom. Anim. Toxins (1) J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Alfieri,A. A. (2) Bicudo,P. L. (2) Chiacchio,S. B. (2) Nascimento,N. (2) Netto,D. P. (2) Balarim,M. R. S. (1) Mais... Palavra-chave Crotalus durissus terrificus (2) Cobalt60 (1) Crotalic antiserum (1) ELISA (1) Gamma irradiated crotalic antisera (1) Gamma radiation (1) Hematology (1) Irradiated crotalic venom (1) Ovine (1) Sheep (1) Snake venom (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2004 (1) 2002 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Humoral response and neutralization capacity of sheep serum inoculated with natural and Cobalt 60-irradiated Crotalus durissus terrificus venom (Laurenti, 1768) J. Venom. Anim. Toxins Netto,D. P.; Chiacchio,S. B.; Bicudo,P. L.; Alfieri,A. A.; Nascimento,N.. The aim of this work was to investigate antigen irradiation on crotalic antivenom and the capacity of sheep as serum producers. Twelve sheep in two groups of six were inoculated with Crotalus durissus terrificus venom. One group was inoculated with natural venom (NV) and the other with Cobalt 60 gamma-irradiated venom (IrV). Three antigen doses were given to the animals at monthly intervals for immunization. The toxic activity of the venom was assessed by LD50 determination in mice. Blood samples were collected weekly analyses of serum neutralization capacity and potency. At the end of the experiment, the animals were challenged with a LD50 for sheep showed no signs of envenoming. These results showed that toxicity of the irradiated venom was 4.4 times... Tipo: Info:eu-repo/semantics/article Palavras-chave: Gamma irradiated crotalic antisera; Snake venom; ELISA; Sheep; Crotalus durissus terrificus; Cobalt60. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302002000200009 Hematological changes in sheep inoculated with natural and Cobalt60-irradiated Crotalus durissus terrificus venom (Laurenti, 1768) J. Venom. Anim. Toxins incl. Trop. Dis. Netto,D. P.; Chiacchio,S. B.; Bicudo,P. L.; Alfieri,A. A.; Balarim,M. R. S.; Nascimento,N.. Natural (NV) and Cobalto60-irradiated (IrV) Crotalus durissus terrificus venom were used to evaluate serum production capacity of sheep and possible hematological and biochemical effects. Freeze-dried venom aliquots were diluted in acidified saline solution (NaCl 150 mM, pH 3.0) and irradiated by a Cobalt 60 source at a dose of 5.54 x 102 Gy/h and a concentration of 2.000 Gy. Twelve sheep were divided into two groups of six animals. One group received irradiated venom (IrV) and the other natural venom (NV). Three antigen doses (venom) were administered at monthly intervals. Blood samples were collected weekly for analysis of serum neutralization potency and capacity, complete blood count (CBC), total plasma protein, fibrinogen, albumin, and globulin. At... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hematology; Gamma radiation; Irradiated crotalic venom; Crotalic antiserum; Ovine; Crotalus durissus terrificus. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992004000100004 Registros recuperados: 2 Primeira ... 1 ... Última

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