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	Provedor de dados BJMBR (2) Autor Biolo,A. (2) Clausell,N. (2) Rohde,L.E. (2) Belló-Klein,A. (1) Martins,S. (1) Mazzotti,N.G. (1) Rosa,A.S. (1) Salvaro,R. (1) Santos,K.G. (1) Silvello,D. (1) Mais... Palavra-chave Heart failure (2) Adrenergic receptor (1) Adrenergic receptors (1) Genetic polymorphisms (1) Polymorphisms (1) Prognosis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2010 (1) 2006 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última The role of adrenergic receptor polymorphisms in heart failure BJMBR Biolo,A.; Rosa,A.S.; Mazzotti,N.G.; Martins,S.; Belló-Klein,A.; Rohde,L.E.; Clausell,N.. The main function of the cardiac adrenergic system is to regulate cardiac work both in physiologic and pathologic states. A better understanding of this system has permitted the elucidation of its role in the development and progression of heart failure. Regardless of the initial insult, depressed cardiac output results in sympathetic activation. Adrenergic receptors provide a limiting step to this activation and their sustained recruitment in chronic heart failure has proven to be deleterious to the failing heart. This concept has been confirmed by examining the effect of ß-blockers on the progression of heart failure. Studies of adrenergic receptor polymorphisms have recently focused on their impact on the adrenergic system regarding its adaptive... Tipo: Info:eu-repo/semantics/article Palavras-chave: Heart failure; Adrenergic receptor; Polymorphisms. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001000003 Impact of β-2 Thr164Ile and combined β-adrenergic receptor polymorphisms on prognosis in a cohort of heart failure outpatients BJMBR Biolo,A.; Salvaro,R.; Clausell,N.; Silvello,D.; Santos,K.G.; Rohde,L.E.. Genetic polymorphisms of adrenergic receptors (ARs) have been associated with the development, progression, and prognosis of patients with heart failure (HF), with few data for the Brazilian population. We evaluated the role of the β2-AR Thr164Ile polymorphism at codon 164 on prognosis in a prospective study on 315 adult Brazilian HF patients, predominantly middle-aged Caucasian men in functional class I-II, with severe left ventricular systolic dysfunction. Genomic DNA was extracted from peripheral blood and β2-AR164 genotypes were detected by PCR followed by restriction fragment length analysis. During a median follow-up of 3 years, 95 deaths occurred and 57 (60%) were HF-related. Unexpectedly, Ile164 carriers (N = 12) had no HF-related events (log-rank... Tipo: Info:eu-repo/semantics/article Palavras-chave: Heart failure; Adrenergic receptors; Genetic polymorphisms; Prognosis. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000600007 Registros recuperados: 2 Primeira ... 1 ... Última

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