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| Desvignes, T.; Fostier, A.; Fauvel, Christian; Bobe, J.. |
| The Nme gene family, also known as Nm23 or NDPK, is a very ancient gene family that can be found in all kingdoms of life. In the late eighties, a gene of the Nme family, NME1, was identified as the first metastatic suppressor gene, resulting in a major interest for this family. Due to the complexity of the family, the need for a unified and evolutionary-supported gene nomenclature was recently stressed by the scientific community. Based on a complete evolutionary history study of the gene family in metazoans and vertebrates, a unified nomenclature was recently proposed and accepted by gene nomenclature consortia. In addition to its well-documented role in tumor metastasis, members of the Nme family are also involved in a wide variety of cellular and... |
| Tipo: Text |
Palavras-chave: Nm23; NDPK; RP2; Teleost; Oocyte; Ovary. |
| Ano: 2013 |
URL: http://archimer.ifremer.fr/doc/00133/24466/22504.pdf |
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| Desvignes, T.; Fauvel, Christian; Bobe, J.. |
| After the recent report of the expression of several nme genes in the zebrafish gonads, the present study aimed at further analyzing the expression of nme genes in the ovary with special attention for the nme transcripts that are maternally inherited and could thus participate in the determination of oocyte developmental competence. The expression levels of all groups I and II nme genes were characterized by QPCR in a panel of zebrafish tissues. The nme genes exhibiting an ovarian expression were subsequently monitored throughout oogenesis and early development, and their expression sites characterized using in situ hybridization. Here, we show that nme2b1, nme3, nme4, and nme6 are highly expressed in the ovary and present in the zebrafish oocyte... |
| Tipo: Text |
Palavras-chave: NDPK; Nm23; Oocyte; Maternal; Teleost; Vertebrate. |
| Ano: 2011 |
URL: http://archimer.ifremer.fr/doc/00051/16226/13778.pdf |
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