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	Provedor de dados BJMBR (2) Autor Bonagamba,L.G.H. (2) Machado,B.H. (2) Zhang,C. (1) Palavra-chave Autonomic regulation (1) Cardiovascular regulation (1) Carotid chemoreceptors (1) NK-1 receptors (1) Substance P (1) Tachykinins (1) Trans-(±)-1-amino-1 3-cyclopentanedicarboxylic acid (1) Trans-(±)-ACPD L-glutamate ionotropic receptors excitatory amino acid receptors neurotransmission baroreflex chloralose anesthesia (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2000 (1) 1998 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Blockade of NK-1 receptors in the lateral commissural nucleus tractus solitarii of awake rats had no effect on the cardiovascular responses to chemoreflex activation BJMBR Zhang,C.; Bonagamba,L.G.H.; Machado,B.H.. The neurotransmission of the chemoreflex in the nucleus tractus solitarii (NTS), particularly of the sympatho-excitatory component, is not completely understood. There is evidence that substance P may play a role in the neurotransmission of the chemoreflex in the NTS. Microinjection of substance P (50 pmol/50 nl, N = 12, and 5 nmol/50 nl, N = 8) into the commissural NTS of unanesthetized rats produced a significant increase in mean arterial pressure (101 ± 1 vs 108 ± 2 and 107 ± 3 vs 115 ± 4 mmHg, respectively) and no significant changes in heart rate (328 ± 11 vs 347 ± 15 and 332 ± 7 vs 349 ± 13 bpm, respectively) 2 min after microinjection. Previous treatment with WIN, an NK-1 receptor antagonist (2.5 nmol/50 nl), microinjected into the NTS of a specific... Tipo: Info:eu-repo/semantics/article Palavras-chave: Tachykinins; Cardiovascular regulation; Carotid chemoreceptors; Autonomic regulation; NK-1 receptors; Substance P. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100018 Cardiovascular responses to microinjection of trans-(±)-ACPD into the NTS were similar in conscious and chloralose-anesthetized rats BJMBR Machado,B.H.; Bonagamba,L.G.H.. The changes in mean arterial pressure (MAP) and heart rate (HR) in response to the activation of metabotropic receptors in the nucleus tractus solitarii (NTS) with trans-(±)-1-amino-1,3-cyclopentanedicarboxylic acid (trans-(±)-ACPD) were evaluated in conscious and anesthetized Wistar, male rats weighing 240-260 g (N = 8). The responses obtained with trans-(±)-ACPD were compared with the responses to L-glutamate (1 nmol/100 nl), since in a previous study we showed that anesthesia converted a pressor response to L-glutamate microinjected into the NTS of conscious rats to a depressor response in the same rats under urethane or chloralose anesthesia. Microinjection of 3 doses of trans-(±)-ACPD (100, 500 and 1000 pmol/100 nl) produced a dose-dependent fall in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trans-(±)-ACPD L-glutamate ionotropic receptors excitatory amino acid receptors neurotransmission baroreflex chloralose anesthesia; Trans-(±)-1-amino-1 3-cyclopentanedicarboxylic acid. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000400016 Registros recuperados: 2 Primeira ... 1 ... Última

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