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Effect of the injection of an extract of Ascaris suum on macrophage activation during the early phase of Mycobacterium bovis BCG infection in C57Bl/6 mice BJMBR
Ferreira,A.P.; Aarestrup,F.M.; Bonecini-Almeida,M.G.; Souza,E.E.; Gomes,E.A.; Corrêa,J.O.A.; Teixeira,H.C..
Injection of an Ascaris suum extract (Asc) affects both the humoral and cellular immune responses to unrelated antigens when it is co-administered with these antigens. In the present study we evaluated the effect of Asc on macrophage activation in the early phase of Mycobacterium bovis BCG (Pasteur strain TMCC 1173) infection in C57Bl/6 mice. C57Bl/6 mice were injected intraperitoneally (ip) with 0.1 mg BCG (BCG group) or BCG plus 1 mg Asc (BCG + Asc group). The peritoneal exudates were obtained at 2, 7 and 14 days after infection. The numbers of IFN-<FONT FACE="Symbol">g</FONT>-secreting cells were assessed by the ELISPOT assay. Nitric oxide (NO) production was measured by the Griess method and by the evaluation of NADPH diaphorase activity in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mycobacterium bovis Ascaris suum macrophage activation TNF-<; FONT FACE=Symbol>; A<; /FONT>; NADPH diaphorase.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100014
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Genetic polymorphisms in vitamin D receptor, vitamin D-binding protein, Toll-like receptor 2, nitric oxide synthase 2, and interferon-γ genes and its association with susceptibility to tuberculosis BJMBR
Leandro,A.C.C.S.; Rocha,M.A.; Cardoso,C.S.A.; Bonecini-Almeida,M.G..
Mycobacterium tuberculosis kills more people than any other single pathogen, with an estimated one-third of the world's population being infected. Among those infected, only 10% will develop the disease. There are several demonstrations that susceptibility to tuberculosis is linked to host genetic factors in twins, family and associated-based case control studies. In the past years, there has been dramatic improvement in our understanding of the role of innate and adaptive immunity in the human host defense to tuberculosis. To date, attention has been paid to the role of genetic host and parasitic factors in tuberculosis pathogenesis mainly regarding innate and adaptive immune responses and their complex interactions. Many studies have focused on the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tuberculosis; Vitamin D; Vitamin D-binding protein; Toll-like receptor; Nitric oxide synthase 2; IFN-γ.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000400002
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