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| Maraschin,M.; Sugui,J.A.; Wood,K.V.; Bonham,C.; Buchi,D.F.; Cantao,M.P.; Carobrez,S.G.; Araujo,P.S.; Peixoto,M.L.; Verpoorte,R.; Fontana,J.D.. |
| Cell cultures of Mandevilla velutina have proved to be an interesting production system for biomass and secondary metabolites able to inhibit the hypotensive activity of bradykinin, a nonapeptide generated in plasma during tissue trauma. The crude ethyl acetate extract of cultured cells contains about 31- to 79-fold more potent anti-bradykinin compounds (e.g., velutinol A) than that obtained with equivalent extracts of tubers. Somaclonal variation may be an explanation for the wide range of inhibitor activity found in the cell cultures. The heterogeneity concerning morphology, differentiation, carbon dissimilation, and velutinol A production in M. velutina cell cultures is reported. Cell cultures showed an asynchronous growth and cells in distinct... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mandevilla velutina; Secondary metabolism; Plant cell cultures; Somaclonal variation; Phytosteroid; Anti-bradykinin compounds. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000600002 |
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