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Late cardiac perconditioning by phenylephrine in an isolated rat heart model is mediated by mitochondrial potassium channels BJPS
Nazari,Afshin; Sedighi,Mehrnoosh; Dalvand,Parvin; Azizi,Yaser; Moghimian,Maryam; Boroujeni,Shakiba Nasiri.
The present study was designed to investigate the effect of early and late administration of phenylephrine during ischemia against regional ischemia-reperfusion injuries in an isolated rat heart model. All animals were randomly divided into experimental groups: (I) IR (Ischemic/ reperfusion): the hearts underwent 35 min of regional ischemia followed by 60 min of reperfusion; (II) 5HD-IR-0: the hearts were perfused for 5 min with 5HD (5-hydroxydecanoate, specific mKATP channel blocker, 100 µM) at the onset of regional ischemia; (III) 5HD-IR-20: the hearts were perfused for 5 min with 5HD 20 min after regional ischemia; (IV) PE-IR-10: the hearts were perfused for 5 min with phenylephrine 10 min after regional ischemia; (V) PE-IR-30: the hearts were perfused...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Phenylephrine; Ischemia; Reperfusion; Preconditioning; Cardioprotection.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100561
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