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| Delmas, Olivier; Holmes, Edward; Talbi, Chiraz; Dacheux, Laurent; Bouchier, Christiane; Larrous, Florence; Bourhy, Hervé. |
| Lyssaviruses are RNA viruses with single-strand, negative-sense genomes responsible for rabies-like diseases in mammals. To date, genomic and evolutionary studies have most often utilized partial genome sequences, particularly of the nucleoprotein and glycoprotein genes, with little consideration of genome-scale evolution. Herein, we report the first genomic and evolutionary analysis using complete genome sequences of all recognised lyssavirus genotypes, including 14 new complete genomes of field isolates from 6 genotypes and one genotype that is completely sequenced for the first time. In doing so we significantly increase the extent of genome sequence data available for these important viruses. Our analysis of these genome sequence data reveals that all... |
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| Ano: 2008 |
URL: http://archimer.ifremer.fr/doc/00139/24994/23092.pdf |
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| Talbi, Chiraz; Lemey, Philippe; Suchard, Marc A.; Abdelatif, Elbia; Elharrak, Mehdi; Nourlil, Jalal; Abdellah, Faouzi; Echevarria, Juan E.; Moron, Sonia Vasquez; Rambaut, Andrew; Campiz, Nicholas; Tatem, Andrew J.; Holmes, Edward; Bourhy, Hervé. |
| Understanding the role of humans in the dispersal of predominately animal pathogens is essential for their control. We used newly developed Bayesian phylogeographic methods to unravel the dynamics and determinants of the spread of dog rabies virus (RABV) in North Africa. Each of the countries studied exhibited largely disconnected spatial dynamics with major geo-political boundaries acting as barriers to gene flow. Road distances proved to be better predictors of the movement of dog RABV than accessibility or raw geographical distance, with occasional long distance and rapid spread within each of these countries. Using simulations that bridge phylodynamics and spatial epidemiology, we demonstrate that the contemporary viral distribution extends beyond that... |
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| Ano: 2010 |
URL: http://archimer.ifremer.fr/doc/00139/24992/23090.pdf |
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| Graham, Stephen C.; Assenberg, René; Delmas, Olivier; Verma, Anil; Gholami, Alireza; Talbi, Chiraz; Owens, Raymond J.; Stuart, David I.; Grimes, Jonathan M.; Bourhy, Hervé. |
| The matrix (M) proteins of rhabdoviruses are multifunctional proteins essential for virus maturation and budding that also regulate the expression of viral and host proteins. We have solved the structures of M from the vesicular stomatitis virus serotype New Jersey (genus: Vesiculovirus) and from Lagos bat virus (genus: Lyssavirus), revealing that both share a common fold despite sharing no identifiable sequence homology. Strikingly, in both structures a stretch of residues from the otherwise-disordered N terminus of a crystallographically adjacent molecule is observed binding to a hydrophobic cavity on the surface of the protein, thereby forming non-covalent linear polymers of M in the crystals. While the overall topology of the interaction is conserved... |
| Tipo: Text |
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| Ano: 2008 |
URL: http://archimer.ifremer.fr/doc/00139/24995/23093.pdf |
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