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	Provedor de dados Nature Precedings (1) Autor Brian A. Cadle (1) Donald C. Cooper (1) Matthew B. Pomrenze (1) Michael V. Baratta (1) Palavra-chave Biotechnology (1) Genetics & Genomics (1) Molecular Cell Biology (1) Neuroscience (1) Pharmacology (1) Tipo do documento Manuscript (1) Ano 2012 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Cocaine self-administration in the mouse: A low-cost, chronic catheter preparation Nature Precedings Matthew B. Pomrenze; Michael V. Baratta; Brian A. Cadle; Donald C. Cooper. Intravenous drug self-administration is the most valid animal model of human addiction because it allows volitional titration of the drug in the blood based on an individual’s motivational state together with the pharmacokinetic properties of the drug. Here we describe a reliable low-cost mouse self-administration catheter assembly and protocol that that can be used to assess a variety of drugs of abuse with a variety of protocols. We describe a method for intravenous catheter fabrication that allows for efficient and long-lasting intravenous drug delivery. The intravenous catheters remained intact and patent for several weeks allowing us to establish stable maintenance of cocaine acquisition. This was followed by a dose response study in the... Tipo: Manuscript Palavras-chave: Biotechnology; Genetics & Genomics; Molecular Cell Biology; Neuroscience; Pharmacology. Ano: 2012 URL: http://precedings.nature.com/documents/7040/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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