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	Provedor de dados 56 (1) Autor Bringaud,F. (1) Hoffmann,P. (1) Périé,J. (1) Soulère,L. (1) Palavra-chave Adenosine (1) Nitric oxide (1) Peroxynitrite (1) S-nitrosothiol (1) Thionitrite (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 1999 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Uptake of NO-releasing drugs by the P2 nucleoside transporter in trypanosomes 56 Soulère,L.; Hoffmann,P.; Bringaud,F.; Périé,J.. Nitric oxide (NO·) has been identified as a principal regulatory molecule of the immune system and the major cytotoxic mediator of activated immune cells. NO· can also react rapidly with a variety of biological species, particularly with the superoxide radical anion O2·- at almost diffusion-limited rates to form peroxynitrite anion (ONOO-). ONOO- and its proton-catalyzed decomposition products are capable of oxidizing a great diversity of biomolecules and can act as a source of toxic hydroxyl radicals. As a consequence, a strategy for the development of molecules with potential trypanocidal activities could be developed to increase the concentration of nitric oxide in the parasites through NO·-releasing compounds. In this way, the rate of formation of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Peroxynitrite; Thionitrite; S-nitrosothiol; Adenosine. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100016 Registros recuperados: 1 Primeira ... 1 ... Última

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