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	Provedor de dados BJMBR (3) Autor Brink,P.R. (3) Christ,G.J. (2) Banach,K. (1) Beyer,E.C. (1) Gemel,J. (1) Larson,D.M. (1) Ricotta,J. (1) Seul,K.H. (1) Mais... Palavra-chave Gap junctions (2) Intercellular communication (2) Vascular smooth muscle (2) Connexin37 (1) Connexin40 (1) Connexin43 (1) Endothelium (1) Heteromeric connexons (1) Rat aorta (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2000 (3) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Biophysical characteristics of gap junctions in vascular wall cells: implications for vascular biology and disease BJMBR Brink,P.R.; Ricotta,J.; Christ,G.J.. The role gap junction channels play in the normal and abnormal functioning of the vascular wall is the subject of much research. The biophysical properties of gap junctions are an essential component in understanding how gap junctions function to allow coordinated relaxation and contraction of vascular smooth muscle. This study reviews the properties thus far elucidated and relates those properties to tissue function. We ask how biophysical and structural properties such as gating, permselectivity, subconductive states and channel type (heteromeric vs homotypic vs heterotypic) might affect vascular smooth muscle tone. Tipo: Info:eu-repo/semantics/article Palavras-chave: Vascular smooth muscle; Gap junctions. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400007 Modulation of intercellular communication by differential regulation and heteromeric mixing of co-expressed connexins BJMBR Beyer,E.C.; Gemel,J.; Seul,K.H.; Larson,D.M.; Banach,K.; Brink,P.R.. Intercellular communication may be regulated by the differential expression of subunit gap junction proteins (connexins) which form channels with differing gating and permeability properties. Endothelial cells express three different connexins (connexin37, connexin40, and connexin43) in vivo. To study the differential regulation of expression and synthesis of connexin37 and connexin43, we used cultured bovine aortic endothelial cells which contain these two connexins in vitro. RNA blots demonstrated discordant expression of these two connexins during growth to confluency. RNA blots and immunoblots showed that levels of these connexins were modulated by treatment of cultures with transforming growth factor-ß1. To examine the potential ability of these... Tipo: Info:eu-repo/semantics/article Palavras-chave: Endothelium; Heteromeric connexons; Intercellular communication; Connexin37; Connexin40. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400004 Gap junctions in isolated rat aorta: evidence for contractile responses that exhibit a differential dependence on intercellular communication BJMBR Christ,G.J.; Brink,P.R.. Connexin43 (Cx43) is a major gap junction protein present in the Fischer-344 rat aorta. Previous studies have identified conditions under which selective disruption of intercellular communication with heptanol caused a significant, readily reversible and time-dependent diminution in the magnitude of <FONT FACE="Symbol">a</font>1-adrenergic contractions in isolated rat aorta. These observations have indentified a significant role for gap junctions in modulating vascular smooth muscle tone. The goal of these steady-state studies was to utilize isolated rat aortic rings to further evaluate the contribution of intercellular junctions to contractions elicited by cellular activation in response to several other vascular spasmogens. The effects of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Gap junctions; Connexin43; Rat aorta; Vascular smooth muscle; Intercellular communication. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400008 Registros recuperados: 3 Primeira ... 1 ... Última

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