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| Foltran,R.K.; Amorim,P.V.G.H.; Duarte,F.H.; Grande,I.P.P.; Freire,A.C.T.B.; Frassetto,F.P.; Dettoni,J.B.; Alves,V.A.; Castro,I.; Trarbach,E.B.; Bronstein,M.D.; Jallad,R.S.. |
| Genetic and functional aberrations of guanine nucleotide-binding protein, alpha stimulating (GNAS), aryl hydrocarbon receptor interacting protein (AIP), and pituitary tumor transforming gene (PTTG) are among the most prominent events in pituitary tumorigenesis. A cohort of Brazilian patients with somatotropinomas (n=41) and non-functioning pituitary adenomas (NFPA, n=21) from a single tertiary-referral center were evaluated for GNAS and AIP mutations and gene expression of AIP and PTTG. Results were compared to the clinical and biological (Ki67 and p53 expression) characteristics of tumors and their response to therapy, if applicable. Genetic analysis revealed that 27% of somatotropinomas and 4.8% of NFPA harbored GNAS mutations (P=0.05). However, no... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Somatotropinomas; Non-functioning pituitary adenomas; PTTG; AIP; GNAS1. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000900601 |
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| Murat,C.B.; Braga,P.B.S.; Fortes,M.A.H.Z.; Bronstein,M.D.; Corrêa-Giannella,M.L.C.; Giorgi,R.R.. |
| The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding the role of the gene in cell proliferation and survival through activation of the PI3K/Akt signaling pathway. Only one Chinese study described somatic mutations and amplification of the PIK3CA gene in a large series of pituitary adenomas. The aim of the present study was to determine genetic alterations of PIK3CA in a second series that consisted of 33 pituitary adenomas of different subtypes diagnosed by immunohistochemistry: 6 adrenocorticotropic hormone-secreting microadenomas, 5 growth hormone-secreting macroadenomas, 7 prolactin-secreting... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pituitary adenomas; PIK3CA proto-oncogene; Genomic amplification; Somatic mutation. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900009 |
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