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| Contreras,H.R.; Paredes,V.; Urquieta,B.; Del Valle,L.; Bustos-Obregón,E.. |
| ParathionÒ is an organophosphorate pesticide amply used in agriculture. Many alterations induced by organophosphorate pesticides have been described, such as: cytogenetic alterations in germinal cells, oligozoospermia and teratozoospermia in the mouse. The effect of ParathionÒ, both pure (PP) and commercial (PC), on mouse interstitial cell testosterone production was evaluated in vivo and in vitro. Male mice were intraperitoneally injected with a single dose of 1/3 LD50 of ParathionÒ, both PP and PC. The animals were sacrificed at 1, 8 and 40 days post injection to evaluate the impact of disrupting testosterone production on spermatogonia, spermatocytes and elongated spermatids. The plasma testosterone was assayed by standard radioimmunoanalysis. The same... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Steroidogenesis; Spermatogenesis; Pesticide; ParathionÒ. |
| Ano: 2006 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452006000300002 |
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