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	Provedor de dados Nature Precedings (2) Autor Byung-Young Park (2) Eun kyu Park (2) Jong Cheon Hahm (2) Michung Yoon (2) Min-Young Kim (2) Yeonhee Hong (2) Dongmin Park (1) Hee Lee (1) Hee Suk Lee (1) Hyunghee Lee (1) Hyunhee Lee (1) Jaeho Oh (1) Jinmi Lee (1) Seolwha Choi (1) Mais... Palavra-chave Biotechnology (1) Pharmacology (1) Tipo do documento Manuscript (2) Ano 2011 (1) 2009 (1) País United Kingdom (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Reduction of adipose tissue mass by the angiogenesis inhibitor ALS-L1023 Nature Precedings Michung Yoon; Hyunhee Lee; Yeonhee Hong; Dongmin Park; Jaeho Oh; Byung-Young Park; Hee Lee; Eun kyu Park; Jong Cheon Hahm; Min-Young Kim. Objective: Angiogenesis has been demonstrated to modulate adipogenesis and obesity. This study was undertaken to determine whether the botanical drug ALS-L1023 (ALS), which exhibits antiangiogenic activity, can regulate adipose tissue growth in high-fat-diet-induced obese mice.Materials and Methods: The effects of ALS on angiogenesis and extracellular matrix remodeling were measured using in vitro assays. The effects of ALS on adipose tissue growth was investigated in nutritionally obese mice. Results: ALS inhibited angiogenesis in a concentration-dependent manner in the tube formation assay and the VEGF-induced proliferation assay using human umbilical vein endothelial cells. ALS also suppressed matrix metalloproteinase (MMP) activity in vitro. ALS... Tipo: Manuscript Palavras-chave: Pharmacology. Ano: 2011 URL: http://precedings.nature.com/documents/6256/version/1 The anti-angiogenic herbal composition Ob-X inhibits adipose tissue growth in obese mice Nature Precedings Min-Young Kim; Jong Cheon Hahm; Byung-Young Park; Hee Suk Lee; Eun kyu Park; Michung Yoon; Jinmi Lee; Yeonhee Hong; Seolwha Choi; Hyunghee Lee. Objective: The growth and development of adipose tissue are thought to be associated with angiogenesis and extracellular matrix remodeling. Since the composition of the herbal extract called Ob-X has been shown to have both anti-angiogenic and matrix metalloproteinase (MMP)-inhibiting activities, we hypothesized that growth of adipose tissue can be regulated by Ob-X. Materials and Methods: The effects of Ob-X on angiogenesis and extracellular matrix remodeling were measured using in vitro and ex vivo assays. The effects of Ob-X on adipose tissue growth were investigated with nutritionally obese mice. Results: Ob-X inhibited angiogenesis in a dose-dependent manner in the human umbilical vein endothelial cell (HUVEC) tube formation assay in vitro and the rat... Tipo: Manuscript Palavras-chave: Biotechnology. Ano: 2009 URL: http://precedings.nature.com/documents/2970/version/1 Registros recuperados: 2 Primeira ... 1 ... Última

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