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| OLIVEIRA,CARLOS H.M.; SIMÃO,ANDERSON A.; TRENTO,MARCUS V.C.; CÉSAR,PEDRO H.S.; MARCUSSI,SILVANA. |
| ABSTRACT The enzyme inhibition by natural and/ or low-cost compounds may represent a valuable adjunct to traditional serotherapy performed in cases of snakebite, mainly with a view to mitigate the local effects of envenoming. The objective of this study was to evaluate possible interactions between vitamins and enzymes that comprise Bothrops atrox and Crotalus durissus terrificus venoms, in vitro. Proteolysis inhibition assays (substrates: azocasein, collagen, gelatin and fibrinogen), hemolysis, coagulation, hemagglutination were carried out using different proportions of vitamins in face of to inhibit minimum effective dose of each venom. The vitamins were responsible for reducing 100% of breaking azocasein by C.d.t. venom, thrombolysis induced by B.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antiophidian properties; Antioxidants; Blood cells; Hemostatic processes; Natural inhibitors. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000502005 |
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| QUEIROZ,ESTELA R.; ABREU,CELESTE M.P. DE; ROCHA,DENISE A.; SOUSA,RAIMUNDO V. DE; FRÁGUAS,RODRIGO M.; BRAGA,MARIANA A.; CÉSAR,PEDRO H.S.. |
| ABSTRACT Dyslipidemias are associated with the incidence of cardiovascular diseases, obesity, diabetes, hypertension and hepatic steatosis, being the cause of morbidity and mortality. This study investigated the effects of lychee peel flour (PF) on serum levels of total cholesterol (TC), low-density lipoprotein (LDL-c), triacylglycerols (TAG) and various parameters related to obesity, in rats fed a hypercholesterolemic diet. Therefore, 20 male rats were used. In the first 21 days, the animals were fed a hypercholesterolemic diet, except for control group. In the following 21 days, their diets were modified, and they received a standard diet (Control); hypercholesterolemic (Hyper); hypercholesterolemic + 5% PF (PF5) and hypercholesterolemic + 10% PF (PF10).... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cholesterol; Lipid peroxidation; Steatosis; Triacylglycerol; Weight gain. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000100267 |
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