|
|
| BORIN,DIEGO B.; MEZZOMO,NATHANA J.; VAUCHER,RODRIGO A.; CARMO,GUILHERME DO; RODRIGUES JUNIOR,LUIZ C.; SULCZEWSKI,FERNANDO B.; SCHWERTZ,CLAITON I.; MENDES,RICARDO E.; DAMIANI,ADRIANI P.; ANDRADE,VANESSA M. DE; RECH,VIRGÍNIA C.; BOECK,CARINA R.. |
| ABSTRACT Creatine acts intracellularly as energy buffer and storage, demonstrating protective effects in animal models of neurodegenerative diseases. However, its permeability throught blood-brain barrier (BBB) is reduced. The aim of the present study was developing a carrier to facilitate the delivery of creatine to the central nervous system. Creatine nanoliposomes were produced, characterized and assayed in models of toxicity in vitro and in vivo. Particles showed negative zeta potential (-12,5 mV), polydispersity index 0.237 and medium-size of 105 nm, which was confirmed by transmission electron microscopy (TEM) images. Toxicity assay in vitro was evaluated with blank liposomes (no drug) or creatine nanoliposomes at concentrations of 0.02 and 0.2... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nanocarrier; Neurodegenerative diseases; Nanotechnology; Liposomes. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000502317 |
| |
