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| CHIPOLINE,INGRID C.; ALVES,EVELYNE; BRANCO,PAOLA; COSTA-LOTUFO,LETICIA V.; FERREIRA,VITOR F.; SILVA,FERNANDO C. DA. |
| ABSTRACT The 1,2-naphthoquinone compound was previously considered active against solid tumors. Moreover, glycosidase inhibitors such as 1,2,3-1H triazoles has been pointed out as efficient compounds in anticancer activity studies. Thus, a series of eleven 1,2-naphthoquinones tethered in C2 to 1,2,3-1H-triazoles 9a-k were designed, synthesized and their cytotoxic activity evaluated using HCT-116 (colon adenocarcinoma), MCF-7 (breast adenocarcinoma) and RPE (human nontumor cell line from retinal epithelium). The chemical synthesis was performed from C-3 allylation of lawsone followed by iodocyclization with subsequent nucleophilic displacement with sodium azide and, finally, the 1,3-dipolar cycloaddition catalyzed by Cu(I) with terminal alkynes led to the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Naphthoquinones lawsone 1; 2; 3-triazoles cancer colon adenocarcinoma breast adenocarcinoma. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301027 |
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