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| CUNHA,KARIN S.; CARUSO,ANABELA C.; FARIA,PAULO A.; SILVA,LICíNIO E. DA; FONSECA,ELIENE C. DA; GELLER,MAURO; MOURA-NETO,RODRIGO S. DE; LOPES,VÂNIA S.. |
| ABSTRACTAIMSTo study the expression of Bcl-2, Bcl-x, as well the presence of cleaved caspase-3 in neurofibromas and malignant peripheral nerve sheath tumors. The expression of Bcl-2 and Bcl-x and the presence of cleaved caspase 3 were compared to clinicopathological features of malignant peripheral nerve sheath tumors and their impact on survival rates were also investigated.MATERIALS AND METHODSThe evaluation of Bcl-2, Bcl-x and cleaved caspase-3 was performed by immunohistochemistry using tissue microarrays in 28 malignant peripheral nerve sheath tumors and 38 neurofibromas. Immunoquantification was performed by computerized digital image analysis.CONCLUSIONSApoptosis is altered in neurofibromas and mainly in malignant peripheral nerve sheath tumors.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Apoptosis regulatory proteins; Malignant peripheral nervous sheath tumors; Neurofibroma; Neurofibromatosis 1. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000401497 |
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