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	Provedor de dados BJPS (1) Autor Caffaro,Arthur Massabki (1) Dezani,André Bersani (1) Pereira,Thaisa Marinho (1) Reis,Juliana Mazza (1) Serra,Cristina Helena dos Reis (1) Palavra-chave Biopharmaceutical Classification System (1) Drugs/dissolution rate (1) Drugs/solubility (1) Intrinsic dissolution/biopharmaceutical classification (1) Intrinsic dissolution/method (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2013 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Equilibrium solubility versus intrinsic dissolution: characterization of lamivudine, stavudine and zidovudine for BCS classification BJPS Dezani,André Bersani; Pereira,Thaisa Marinho; Caffaro,Arthur Massabki; Reis,Juliana Mazza; Serra,Cristina Helena dos Reis. Solubility and dissolution rate of drugs are of major importance in pre-formulation studies of pharmaceutical dosage forms. The solubility improvement allows the drugs to be potential biowaiver candidates and may be a good way to develop more dose-efficient formulations. Solubility behaviour of lamivudine, stavudine and zidovudine in individual solvents (under pH range of 1.2 to 7.5) was studied by equilibrium solubility and intrinsic dissolution methods. In solubility study by equilibrium method (shake-flask technique), known amounts of drug were added in each media until to reach saturation and the mixture was subjected to agitation of 150 rpm for 72 hours at 37 ºC. In intrinsic dissolution test, known amount of each drug was compressed in the matrix of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Drugs/solubility; Drugs/dissolution rate; Intrinsic dissolution/method; Intrinsic dissolution/biopharmaceutical classification; Biopharmaceutical Classification System. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400026 Registros recuperados: 1 Primeira ... 1 ... Última

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