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Emodin protects H9c2 cells from hypoxia-induced injury by up-regulating miR-138 expression BJMBR
Zhang,Xuezhi; Qin,Qiaoji; Dai,Hongyan; Cai,Shanglang; Zhou,Changyong; Guan,Jun.
Myocardial infarction (MI) is a common presentation for ischemic heart disease, which is a leading cause of death. Emodin is a Chinese herbal anthraquinone used in several diseases. However, the effect of emodin in hypoxia-induced injury in cardiomyocytes has not been clearly elucidated. Our study aimed to clarify the functions of emodin in hypoxia-induced injury in rat cardiomyocytes H9c2 and explore the underlying mechanism. The effects of emodin on cell viability and apoptosis were analyzed by the Cell counting kit-8 assay and flow cytometry assay, respectively. The cell proliferation- and cell apoptosis-related proteins were detected by western blot. qRT-PCR was used to determine the relative expression of miR-138. Cell transfection was performed to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Emodin; Myocardial infarction; Hypoxia injury; MiR-138; Sirt1/AKT pathway; Wnt/β-catenin pathway.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000300603
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