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| Peixoto,T.C.; Moura,E.G.; Oliveira,E.; Younes-Rapozo,V.; Soares,P.N.; Rodrigues,V.S.T.; Santos,T.R.; Peixoto-Silva,N.; Carvalho,J.C.; Calvino,C.; Conceição,E.P.S.; Guarda,D.S.; Claudio-Neto,S.; Manhães,A.C.; Lisboa,P.C.. |
| Maternal smoking is a risk factor for progeny obesity. We have previously shown, in a rat model of neonatal tobacco smoke exposure, a mild increase in food intake and a considerable increase in visceral adiposity in the adult offspring. Males also had secondary hyperthyroidism, while females had only higher T4. Since brown adipose tissue (BAT) hypofunction is related to obesity, here we tested the hypothesis that higher levels of thyroid hormones are not functional in BAT, suggesting a lower metabolic rate. We evaluated autonomic nerve activity in BAT and its function in adult rats that were exposed to tobacco smoke during lactation. At birth, litters were adjusted to 3 male and 3 female pups/litter. From postnatal day (PND) 3 to 21, Wistar lactating rats... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tobacco smoke Suckling period Developmental plasticity; Obesity Autonomic function. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000600602 |
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