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	Provedor de dados BJMBR (2) Autor Campos,A.H. (2) Lima,V.C. (1) Rosa,W.C.M. (1) Schor,N. (1) Palavra-chave Calcium oxalate (1) Coronary artery angioplasty (1) Coronary restenosis (1) DCK cells (1) Immunosuppression (1) Inflammation mediators (1) Mechanisms of endocytosis (1) Oral sirolimus (1) Percutaneous coronary intervention (1) Renal stone (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2010 (1) 2000 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Mechanisms involved in calcium oxalate endocytosis by Madin-Darby canine kidney cells BJMBR Campos,A.H.; Schor,N.. Calcium oxalate (CaOx) crystals adhere to and are internalized by tubular renal cells and it seems that this interaction is related (positively or negatively) to the appearance of urinary calculi. The present study analyzes a series of mechanisms possibly involved in CaOx uptake by Madin-Darby canine kidney (MDCK) cells. CaOx crystals were added to MDCK cell cultures and endocytosis was evaluated by polarized light microscopy. This process was inhibited by an increase in intracellular calcium by means of ionomycin (100 nM; N = 6; 43.9% inhibition; P<0.001) or thapsigargin (1 µM; N = 6; 33.3% inhibition; P<0.005) administration, and via blockade of cytoskeleton assembly by the addition of colchicine (10 µM; N = 8; 46.1% inhibition;... Tipo: Info:eu-repo/semantics/article Palavras-chave: Calcium oxalate; DCK cells; Mechanisms of endocytosis; Renal stone. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100015 Effect of oral sirolimus therapy on inflammatory biomarkers following coronary stenting BJMBR Rosa,W.C.M.; Campos,A.H.; Lima,V.C.. We studied the effect of oral sirolimus, administered to prevent and treat in-stent restenosis (ISR), on the variation of serum levels of inflammatory markers following coronary stenting with bare metal stents. The mean age of the patients was 56 ± 13 years, 65% were males and all had clinically manifested ischemia. Serum levels of high sensitivity C-reactive protein (hs-CRP) concentration were determined by chemiluminescence and serum levels of all other biomarkers by ELISA. One group of patients at high risk for ISR received a loading oral dose of 15 mg sirolimus and 5 mg daily thereafter for 28 days after stenting (SIR-G). A control group (CONT-G) was submitted to stenting without sirolimus therapy. The increase in hs-CRP concentration was highest at 24... Tipo: Info:eu-repo/semantics/article Palavras-chave: Inflammation mediators; Oral sirolimus; Percutaneous coronary intervention; Coronary artery angioplasty; Coronary restenosis; Immunosuppression. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000800012 Registros recuperados: 2 Primeira ... 1 ... Última

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