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Neuroprotective effect of ketamine/xylazine on two rat models of Parkinson's disease BJMBR
Ferro,M.M.; Angelucci,M.E.M.; Anselmo-Franci,J.A.; Canteras,N.S.; Da Cunha,C..
There is a great concern in the literature for the development of neuroprotectant drugs to treat Parkinson's disease. Since anesthetic drugs have hyperpolarizing properties, they can possibly act as neuroprotectants. In the present study, we have investigated the neuroprotective effect of a mixture of ketamine (85 mg/kg) and xylazine (3 mg/kg) (K/X) on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 6-hydroxydopamine (6-OHDA) rat models of Parkinson's disease. The bilateral infusion of MPTP (100 µg/side) or 6-OHDA (10 µg/side) into the substantia nigra pars compacta of adult male Wistar rats under thiopental anesthesia caused a modest (~67%) or severe (~91%) loss of tyrosine hydroxylase-immunostained cells, respectively. On the other hand, an...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Neuroprotection 6-Hydroxydopamine 1-Methyl-4-phenyl-1; 2; 3; 6- tetrahydropyridine Ketamine Parkinson's disease.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000100012
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Morphine infusions into the rostrolateral periaqueductal gray affect maternal behaviors BJMBR
Moura,L.M.; Canteras,N.S.; Sukikara,M.H.; Felicio,L.F..
It is well established that morphine inhibits maternal behaviors. Previous studies by our group have shown activation of the rostrolateral periaqueductal gray (rlPAG) upon inhibition-intended subcutaneous injections of morphine. In this context, we demonstrated that a single naloxone infusion into the rlPAG, following this opioid-induced inhibition, reactivated maternal behaviors. Since these data were obtained by using peripheral morphine injections, the present study was designed to test whether morphine injected directly into the rlPAG would affect maternal behaviors. Our hypothesis that morphine acting through the rlPAG would disrupt maternal behaviors was confirmed with a local infusion of morphine. The mothers showed shorter latency for locomotor...
Tipo: Info:eu-repo/semantics/article Palavras-chave: PAG; Maternal behaviors; Lactation; Opiate; Active behavior.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000900013
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c-Fos expression induced by electroacupuncture at the Zusanli point in rats submitted to repeated immobilization BJMBR
Medeiros,M.A.; Canteras,N.S.; Suchecki,D.; Mello,L.E.A.M..
In laboratory animals, acupuncture needs to be performed on either anesthetized or, if unanesthetized, restrained subjects. Both procedures up-regulate c-Fos expression in several areas of the central nervous system, representing therefore a major pitfall for the assessment of c-Fos expression induced by electroacupuncture. Thus, in order to reduce the effect of acute restraint we used a protocol of repeated restraint for the assessment of the brain areas activated by electroacupuncture in adult male Wistar rats weighing 180-230 g. Repeated immobilization protocols (6 days, 1 h/day and 13 days, 2 h/day) were used to reduce the effect of acute immobilization stress on the c-Fos expression induced by electroacupuncture at the Zusanli point (EA36S). Animals...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acupuncture; Zusanli point; Immediate early genes; C-Fos; Restraint; Habituation.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001200009
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What ethologically based models have taught us about the neural systems underlying fear and anxiety BJMBR
Canteras,N.S.; Mota-Ortiz,S.R.; Motta,S.C..
Classical Pavlovian fear conditioning to painful stimuli has provided the generally accepted view of a core system centered in the central amygdala to organize fear responses. Ethologically based models using other sources of threat likely to be expected in a natural environment, such as predators or aggressive dominant conspecifics, have challenged this concept of a unitary core circuit for fear processing. We discuss here what the ethologically based models have told us about the neural systems organizing fear responses. We explored the concept that parallel paths process different classes of threats, and that these different paths influence distinct regions in the periaqueductal gray - a critical element for the organization of all kinds of fear...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fear; Predator exposure; Social threat; Fear memory; Contextual fear; Hypothalamus.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000400006
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