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| Silva,Isabel Cristina Vieira da; Oliveira,Pollyana Felix de; Barbosa,Gleyce Moreno; Wessjohann,Ludger A.; Cardozo-Filho,Lucio; Holandino,Carla; Muzitano,Michelle Frazão; Leal,Ivana Correa Ramos. |
| Cancer is one of the most prevalent diseases worldwide and the natural products could be a source of bioactive compounds. Passiflora mucronata (PM) belongs to a very known vegetal genus, although, there are no studies about cytotoxic activity or isolated compounds. Different extracts from PM were obtained by liquid-liquid partition (P), Soxhlet (Sox) and supercritical fluid (SFE1-5) extraction techniques, being compared concerning their yields, chemical profile and cytotoxicity. The Sox extracts showed the highest yields (6.03%: hexane; 2.51%: dichloromethane) followed by SFE (from 4.34 to 1.63%) and partitions (1.06 and 2.26%). The hexane partition (HP) showed the best cytotoxic activity against K562 cell line (IC50 = 18.72 µg.mL-1). From HP, the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Apoptosis; Cytotoxic; Passiflora mucronata; Stigmasterol; Triterpenes. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100510 |
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