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	Provedor de dados 56 (4) Autor Auler Jr.,J.O.C. (4) Carmona,M.J.C. (4) Malbouisson,L.M.S. (4) Pereira,V.A. (2) Santos,S.R.C.J. (2) Barbalho,L. (1) Barbas,C.V. (1) Bertoline,M.A. (1) Carvalho,C.R.R. (1) Le Bihan,K.B. (1) Massoco,C.O. (1) Omosako,C.E.K. (1) Pelosi,P. (1) Saldiva,P.H.N. (1) Szeles,T.F. (1) Mais... Palavra-chave Cardiopulmonary bypass (2) Pharmacokinetics (2) Propranolol (2) Atenolol (1) Coronary artery bypass grafting surgery (1) Cytokines (1) Hemodynamics (1) Inflammation (1) Lung hyperinflation (1) PEEP (1) Postoperative cardiac surgery (1) Respiratory mechanics (1) Ventilator-induced lung injury (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Ano 2010 (1) 2009 (1) 2005 (1) 2000 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última The effects of positive end-expiratory pressure on respiratory system mechanics and hemodynamics in postoperative cardiac surgery patients 56 Auler Jr.,J.O.C.; Carmona,M.J.C.; Barbas,C.V.; Saldiva,P.H.N.; Malbouisson,L.M.S.. We prospectively evaluated the effects of positive end-expiratory pressure (PEEP) on the respiratory mechanical properties and hemodynamics of 10 postoperative adult cardiac patients undergoing mechanical ventilation while still anesthetized and paralyzed. The respiratory mechanics was evaluated by the inflation inspiratory occlusion method and hemodynamics by conventional methods. Each patient was randomized to a different level of PEEP (5, 10 and 15 cmH2O), while zero end-expiratory pressure (ZEEP) was established as control. PEEP of 15-min duration was applied at 20-min intervals. The frequency dependence of resistance and the viscoelastic properties and elastance of the respiratory system were evaluated together with hemodynamic and respiratory... Tipo: Info:eu-repo/semantics/article Palavras-chave: Postoperative cardiac surgery; PEEP; Respiratory mechanics; Hemodynamics. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100005 Effect of cardiopulmonary bypass on the pharmacokinetics of propranolol and atenolol 56 Carmona,M.J.C.; Pereira,V.A.; Malbouisson,L.M.S.; Auler Jr.,J.O.C.; Santos,S.R.C.J.. The pharmacokinetics of some β-blockers are altered by cardiopulmonary bypass (CPB). The objective of this study was to compare the effect of coronary artery bypass graft (CABG) surgery employing CPB on the pharmacokinetics of propranolol and atenolol. We studied patients receiving oral propranolol with doses ranging from 80 to 240 mg (N = 11) or atenolol with doses ranging from 25 to 100 mg (N = 8) in the pre- and postoperative period of CABG with moderately hypothermic CPB (32°C). On the day before and on the first day after surgery, blood samples were collected before β-blocker administration and every 2 h thereafter. Plasma levels were determined using high-performance liquid chromatography and data were treated by pharmacokinetics-modelling.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Propranolol; Atenolol; Pharmacokinetics; Coronary artery bypass grafting surgery; Cardiopulmonary bypass. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600016 Lung hyperinflation stimulates the release of inflammatory mediators in spontaneously breathing subjects 56 Malbouisson,L.M.S.; Szeles,T.F.; Barbalho,L.; Massoco,C.O.; Carmona,M.J.C.; Carvalho,C.R.R.; Pelosi,P.; Auler Jr.,J.O.C.. Lung hyperinflation up to vital capacity is used to re-expand collapsed lung areas and to improve gas exchange during general anesthesia. However, it may induce inflammation in normal lungs. The objective of this study was to evaluate the effects of a lung hyperinflation maneuver (LHM) on plasma cytokine release in 10 healthy subjects (age: 26.1 ± 1.2 years, BMI: 23.8 ± 3.6 kg/m²). LHM was performed applying continuous positive airway pressure (CPAP) with a face mask, increased by 3-cmH2O steps up to 20 cmH2O every 5 breaths. At CPAP 20 cmH2O, an inspiratory pressure of 20 cmH2O above CPAP was applied, reaching an airway pressure of 40 cmH2O for 10 breaths. CPAP was then decreased stepwise. Blood samples were collected before and 2 and 12 h after LHM.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Lung hyperinflation; Ventilator-induced lung injury; Inflammation; Cytokines. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000200011 Cardiopulmonary bypass alters the pharmacokinetics of propranolol in patients undergoing cardiac surgery 56 Carmona,M.J.C.; Malbouisson,L.M.S.; Pereira,V.A.; Bertoline,M.A.; Omosako,C.E.K.; Le Bihan,K.B.; Auler Jr.,J.O.C.; Santos,S.R.C.J.. The pharmacokinetics of propranolol may be altered by hypothermic cardiopulmonary bypass (CPB), resulting in unpredictable postoperative hemodynamic responses to usual doses. The objective of the present study was to investigate the pharmacokinetics of propranolol in patients undergoing coronary artery bypass grafting (CABG) by CPB under moderate hypothermia. We evaluated 11 patients, 4 women and 7 men (mean age 57 ± 8 years, mean weight 75.4 ± 11.9 kg and mean body surface area 1.83 ± 0.19 m²), receiving propranolol before surgery (80-240 mg a day) and postoperatively (10 mg a day). Plasma propranolol levels were measured before and after CPB by high-performance liquid chromatography. Pharmacokinetic Solutions 2.0 software was used to estimate the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Propranolol; Pharmacokinetics; Cardiopulmonary bypass. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500008 Registros recuperados: 4 Primeira ... 1 ... Última

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