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	Provedor de dados BJMBR (2) Autor Carneiro,F.S. (2) Lima,V.V. (2) Tostes,R.C. (2) Webb,R.C. (2) Brands,M.W. (1) Carneiro,Z.N. (1) Giachini,F.R. (1) Giachini,F.R.C. (1) Hannan,J.L. (1) Mais... Palavra-chave Ca2+ influx (1) Ca2+ release-activated Ca2+ channel (1) Intracellular Ca2+ store (1) Na+/K+-ATPase pump (1) Oscillatory activity (1) Ouabain (1) Sarcoplasmic reticulum (1) Small mesenteric arteries (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2011 (1) 2009 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg BJMBR Giachini,F.R.; Lima,V.V.; Hannan,J.L.; Carneiro,F.S.; Webb,R.C.; Tostes,R.C.. Highly efficient mechanisms regulate intracellular calcium (Ca2+) levels. The recent discovery of new components linking intracellular Ca2+ stores to plasma membrane Ca2+ entry channels has brought new insight into the understanding of Ca2+ homeostasis. Stromal interaction molecule 1 (STIM1) was identified as a Ca2+ sensor essential for Ca2+ store depletion-triggered Ca2+ influx. Orai1 was recognized as being an essential component for the Ca2+ release-activated Ca2+ (CRAC) channel. Together, these proteins participate in store-operated Ca2+ channel function. Defective regulation of intracellular Ca2+ is a hallmark of several diseases. In this review, we focus on Ca2+ regulation by the STIM1/Orai1 pathway and review evidence that implicates STIM1/Orai1 in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ca2+ release-activated Ca2+ channel; Sarcoplasmic reticulum; Intracellular Ca2+ store; Ca2+ influx. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100002 A key role for Na+/K+-ATPase in the endothelium-dependent oscillatory activity of mouse small mesenteric arteries BJMBR Giachini,F.R.C.; Carneiro,F.S.; Lima,V.V.; Carneiro,Z.N.; Brands,M.W.; Webb,R.C.; Tostes,R.C.. Oscillatory contractile activity is an inherent property of blood vessels. Various cellular mechanisms have been proposed to contribute to oscillatory activity. Mouse small mesenteric arteries display a unique low frequency contractile oscillatory activity (1 cycle every 10-12 min) upon phenylephrine stimulation. Our objective was to identify mechanisms involved in this peculiar oscillatory activity. First-order mesenteric arteries were mounted in tissue baths for isometric force measurement. The oscillatory activity was observed only in vessels with endothelium, but it was not blocked by L-NAME (100 µM) or indomethacin (10 µM), ruling out the participation of nitric oxide and prostacyclin, respectively, in this phenomenon. Oscillatory activity was not... Tipo: Info:eu-repo/semantics/article Palavras-chave: Oscillatory activity; Na+/K+-ATPase pump; Ouabain; Small mesenteric arteries. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100010 Registros recuperados: 2 Primeira ... 1 ... Última

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