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Production, solubility and antioxidant activity of curcumin nanosuspension Ciênc. Tecnol. Aliment.
Carvalho,Deivis de Moraes; Takeuchi,Katiuchia Pereira; Geraldine,Robson Maia; Moura,Celso José de; Torres,Maria Célia Lopes.
Curcumin is a powerful bioactive agent and natural antioxidant, but it is practically water-insoluble and has low bioavailability; a possible solution to this obstacle would be formulations of curcumin nanoparticles. Surfactants such as tween 80 can be used to stabilize low-solubility molecules preventing particle aggregation. The objectives of this study were the preparation of a suspension with curcumin nanoparticles in tween 80, the testing of pure curcumin solubility and of a simple mixture of curcumin with tween 80 and nanosuspension in water and ethanol as solvents, and finally the assessment of the antioxidant activity. We prepared the nanosuspension by injecting a curcumin solution in dichloromethane at low flow in water with tween 80 under heating...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Curcumin; Nanoparticles; Solubility; Antioxidant.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612015000100115
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