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	Provedor de dados BJID (2) Autor Brindeiro,Rodrigo (2) Carvalho,Denise Siqueira de (2) Queiroz-Telles,Flávio de (2) Toledo,Paula Virginia Michelon (2) Cunha,Clovis Arns da (1) Marcinko,Gustavo (1) Romagnoli,Luiza (1) Rossi,Silvia Gomes de (1) Souza,Margely Nunes de (1) Mais... Palavra-chave Genotype (2) Antiretroviral (1) Antiretrovirals (1) Drug experienced patients (1) Drug-experienced patients (1) HIV-1 (1) HIV-1 subtypes (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2010 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Genetic diversity of human immunodeficiency virus-1 isolates in Paraná, Brazil BJID Toledo,Paula Virginia Michelon; Carvalho,Denise Siqueira de; Rossi,Silvia Gomes de; Brindeiro,Rodrigo; Queiroz-Telles,Flávio de. OBJECTIVE: Because epidemiological data on circulating HIV subtypes among HIV-positive patients in the state of Paraná were not known until now, the aims of this study were to describe the genetic diversity profile of HIV-1 in treated patients in Paraná, Brazil, and report the differences in protease (PR) and reverse transcriptase (RT) mutations in HIV-1 subtypes. PATIENTS AND METHODS: A cross-sectional study was conducted from 2003 to 2006. Plasma viral RNA of 389 patients was extracted and PR and RT genes were polymerase chain reaction-amplified and sequenced. Sequences were subtyped and examined for antiretroviral resistance mutations. Data on gender of patient harboring the viruses and past history of antiretroviral treatment were also collected.... Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV-1 subtypes; Genotype; Antiretroviral; Drug experienced patients. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300006 HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil BJID Toledo,Paula Virginia Michelon; Carvalho,Denise Siqueira de; Romagnoli,Luiza; Marcinko,Gustavo; Cunha,Clovis Arns da; Souza,Margely Nunes de; Brindeiro,Rodrigo; Queiroz-Telles,Flávio de. Antiretroviral therapy (ART) has reduced morbidity and mortality related to human immunodeficiency virus (HIV) infection, but in spite of this advance, HIV mutations decrease antiretroviral susceptibility, thus contributing to treatment failure in patients. Genotyping HIV-1 allows the selection of new drugs after initial drug failure. This study evaluated the genotypic profile of HIV-1 isolates from treated (drug-experienced) patients in Paraná, Brazil. The prevalence of mutations in reverse transcriptase (RT) and protease (PR) genes were assessed. We analyzed 467 genotypes of patients with HIV-1 viral loads above 1,000 copies/mL. Mutations at HIV-1 RT and PR genes and previously used ART regimens were recorded. The most prevalent RT mutations were: 184V... Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV-1; Genotype; Antiretrovirals; Drug-experienced patients. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400009 Registros recuperados: 2 Primeira ... 1 ... Última

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