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| Carvalho,Flávia Chiva; Bruschi,Marcos Luciano; Evangelista,Raul Cesar; Gremião,Maria Palmira Daflon. |
| Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mucoadhesion; Bioadhesion; Mucoadhesive systems; Drugs/delivery. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000100002 |
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| Cazedey,Edith Cristina Laignier; Carvalho,Flávia Chiva; Fiorentino,Flávia Angélica Másquio; Gremião,Maria Palmira Daflon; Salgado,Hérida Regina Nunes. |
| Tests in animals are used as models in toxicological and investigative studies. However, such tests have been considered inhumane because they can cause pain and suffering to experimental animals, while these methods can often be subjective. Protests calling for animal protection have questioned the effectiveness of in vivo tests and suggest the introduction of alternative, in vitro methods. International organizations, such as the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), the National Institute of Health (NIH), the Organization for Economic Co-operation and Development (OECD), that regulate and develop new alternative animal models, have indicated the running of preliminary assays and execution of sequential... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Animal experimentation/alternative methods in vitro; Experiments/in vitro methods; Corrositex®/in vitro method/experiments; BCOP/in vitro method/experiments; HET-CAM/in vitro method/experiments. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400021 |
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| Lacerda,Gabriel José Silveira; Piantino,Beatriz Lemos; Gonzaga,Edeilson Vitor; Naves,Valéria de Moura Leite; Pedreiro,Liliane Neves; Gremião,Maria Palmira Daflon; Pereira,Gislaine Ribeiro; Carvalho,Flávia Chiva. |
| This study evaluates various techniques for producing mesalamine (5ASA)-loaded particles employing chitosan as a biopolymer: (1) the polyelectrolyte complexation of chitosan with phthalate hypromelose (HP), (2) the chemical crosslinking of chitosan with genipin and (3) the water-in-oil emulsion method associated with chemical crosslinking with genipin. Systems were characterized by dynamic light scattering, zeta potential (ζ), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR) and a drug release profile. Method (1) was efficiently produced unloaded nanoparticles (491 nm, PdI=0.26 and ζ = 23.2), but the conditions for chitosan and HP cross-linking enhanced the precipitation of 5ASA. Method (2) caused the degradation of the drug.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Emulsion method; Polyelectrolyte crosslinking; Chemical cross-linking; Chitosan; Mesalazine. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100602 |
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