Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados Genet. Mol. Biol. (3) Autor Carvalho,José Carlos Tavares (3) Maistro,Edson Luis (3) Cascon,Vera (1) Espósito,Anderson Victorino (1) Kaplan,Maria Auxiliadora Coelho (1) Pereira,Danielli Maria Vieira (1) Rocha,Leandro Machado (1) Souza,Andréa Bêcco de (1) Souza,Lilian Mara Silva (1) Mais... Palavra-chave Chromosome aberrations (3) Micronucleus test (3) Caesalpinia ferrea (1) Copaifera duckei (Caesalpinaceae) (1) Cytotoxic effect (1) Hypericum brasiliense (1) Phytochemical characterization (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2006 (1) 2005 (2) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última No clastogenic activity of Caesalpinia ferrea Mart. (Leguminosae) extract on bone marrow cells of Wistar rats Genet. Mol. Biol. Souza,Andréa Bêcco de; Souza,Lilian Mara Silva; Carvalho,José Carlos Tavares; Maistro,Edson Luis. Extracts of the fruits of Caesalpinia ferrea Mart. (Leguminosae) are widely consumed in folkloric medicine in Brazil and several other countries without any genetic toxicity evaluation. In this study we investigated, the clastogenic and cytotoxic potential of the crude aqueous extract of the fruits of C. ferrea in Wistar rat bone marrow cells using the micronucleus and chromosomal aberration test systems. The animals were treated by gavage with 3 concentrations of the extract, 500, 1000 and 1500 mg/kg, and cyclophosphamide 30 mg/kg. Bone marrow cells were collected 24 h after the treatment. There was no statistically significant difference in the mean of micronucleated polychromatic erythrocytes (MNPCE), mean number of chromosomal aberrations or mitotic... Tipo: Info:eu-repo/semantics/article Palavras-chave: Caesalpinia ferrea; Micronucleus test; Chromosome aberrations. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000200028 Evaluation of the genotoxic potential of the Hypericum brasiliense (Guttiferae) extract in mammalian cell system in vivo Genet. Mol. Biol. Espósito,Anderson Victorino; Pereira,Danielli Maria Vieira; Rocha,Leandro Machado; Carvalho,José Carlos Tavares; Maistro,Edson Luis. Plants of the genus Hypericum, long used in folk medicine, contain active compounds which present, anti-septic, diuretic, digestive, expectorant, vermifugal, anti-depressive and other properties. The possible clastogenic effect of a H. brasiliense extract was tested in vivo on the bone marrow cells of Wistar rats. The extract was administered by gavage at doses of 50, 150 and 300 mg/kg body weight. Experimental and control animals were submitted to euthanasia 24 h after the treatment for micronucleus (MN) and chromosome preparations. H. brasiliense extract did not induce statistically significant increases in the average numbers of MN or chromosome aberrations in the test systems employed. Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypericum brasiliense; Micronucleus test; Chromosome aberrations. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000100026 In vivo evaluation of the mutagenic potential and phytochemical characterization of oleoresin from Copaifera duckei Dwyer Genet. Mol. Biol. Maistro,Edson Luis; Carvalho,José Carlos Tavares; Cascon,Vera; Kaplan,Maria Auxiliadora Coelho. We characterized the chemical constituents of Copaifera duckei oleoresin and used dermal application to Wistar rats to evaluated its possible mutagenic and cytotoxic activities on peripheral blood reticulocytes and bone marrow cells. Chemical characterization of the oleoresin revealed the presence of sesquiterpene hydrocarbons, an unidentified neutral diterpene and diterpene acids. To evaluate mutagenicity evaluation the rats were treated with 10, 25 and 50% of the LD50 dose of the oleoresin for three consecutive days and peripheral blood collected after 0, 24, 48 and 72 h for micronucleus analysis. The rats were humanly sacrificed 24 hours after the last treatment and chromosome preparations made using standard techniques. At the three concentrations and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Copaifera duckei (Caesalpinaceae); Phytochemical characterization; Micronucleus test; Chromosome aberrations; Cytotoxic effect. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000500028 Registros recuperados: 3 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco